1. The synthesis of new biomaterials based on metallic nanoparticles and biologically active natural compounds isolated from some Romanian native plants from Adoxaceae and Cornaceae family. 2. The preparation of new organic-anorganic hybrid biomaterials obtained from synthetic derivatives of anthocyanins isolated from fruits of above mentioned plants. 3. The characterization of isolated bioactive natural compounds and synthetized biomaterials by HPLC, UV-Vis, fluorescence and FTIR spectroscopy, transmission electron microscopy (TEM) and X-ray diffraction (XRD). 4. The evaluation of the biological activity (citotoxicity and antiinflammatory effect) of the new materials. 5. The elaboration of some new dermatological products based on the hybrid bionanomaterials. Stage I 15/12/2012 New biomaterialsbased on metalic nanoparticles functionalized with natural compounds obtained from fruits of some plants from Adoxaceae family. Stage II 10/12/2013 Dermatologic products based on new biomaterials obtained from natural compounds from fruits of some plants from Cornaceae family and metal nanoparticles. Stage III 10/12/2014 Dermatologic products based on new biomaterials obtained from natural compounds from fruits of some plants from Cornaceae family and metal nanoparticles. Dermatologic products based on new biomaterials obtaine from metalic nanoparticles functionalized with semisinthetized compounds derived from anthocyanines Stage IV 01/07/2015 Optimization of the results